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On Immunological Memory as a Function of a Recursive Proliferation Process

We present a model that explains immunological memory as a consequence of the recursive proliferation of reactive and suppressive cells, where the relative proportion of these cells will set a probability for the emergence of a response (inflammation). We show that the underlying principle of the proposed model is a special case of Polya's urn process. This insight reveals and explains the emergent functionality of the model. Additionally, experiments and simulations are performed to validate the obtained insight of the model.

On Immunological Memory as a Function of a Recursive Proliferation Process

15th IEEE International Conference on Engineering of Complex Computer Systems

Authors: Thomas Stibor and Anastasio Salazar-Banuelos
Year/month: 2010/
Booktitle: 15th IEEE International Conference on Engineering of Complex Computer Systems
Address: Oxford, England
Publisher: IEEE Press
Fulltext: iceccs2010.pdf

Abstract

We present a model that explains immunological memory as a consequence of the recursive proliferation of reactive and suppressive cells, where the relative proportion of these cells will set a probability for the emergence of a response (inflammation). We show that the underlying principle of the proposed model is a special case of Polya's urn process. This insight reveals and explains the emergent functionality of the model. Additionally, experiments and simulations are performed to validate the obtained insight of the model.

Bibtex:

@inproceedings { Stibor:Salazar:2010,
author = { Thomas Stibor and Anastasio Salazar-Banuelos},
title = { On Immunological Memory as a Function of a Recursive Proliferation Process },
year = { 2010 },
booktitle = { 15th IEEE International Conference on Engineering of Complex Computer Systems },
address = { Oxford, England },
publisher = { IEEE Press },
url = {https://www.sec.in.tum.de/i20/publications/on-immunological-memory-as-a-function-of-a-recursive-proliferation-process/@@download/file/iceccs2010.pdf}
}